| Autor: |
Tomić, Martina, Vrabec, Romano, Bulum, Tomislav, Roso, Vinko, Vučković-Rebrina, Sandra, Vučić Lovrenčić, Marijana, Smirčić-Duvnjak, Lea |
| Přispěvatelé: |
Bandello, Francesco M. |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Popis: |
Purpose. To investigate the relationship between adipocytokines, obesity and endothelial function, and their association with diabetic retinopathy (DR) in patients with type 1 diabetes. Methods. This cross-sectional study included 189 type 1 diabetic patients (109M/80F) with median age 46 years and median diabetes duration 13 years. Glycated hemoglobin (HbA1c), total cholesterol, HDL and LDL cholesterol, triglycerides (TG) and serum creatinine were determined using routine laboratory methods. Urinary albumin excretion rate (UAE) was measured from a 24-hr urine sample. Adiponectin, leptin and resistin were determined by ELISA method. Anthropometric parameters assessed were body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR). Central augmentation index (cAIx) and pulse wave velocity (PWV) were obtained using SphygmoCor device. Ophthalmologic examination included color fundus photography according to the EURODIAB methodology. Patients with severe nonproliferative DR (NPDR) or proliferative DR were not included in the study. Results. Patients were divided into two groups: group 1 (no retinopathy ; n=157) and group 2 (mild/moderate NPDR ; n=32). The groups did not differ in the values of metabolic markers, serum creatinine, UAE and adiponectin. Group 2 had longer diabetes duration (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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