| Autor: |
Mavrinac, Vojko, Mikolašević, Ivana, Orlić, Lidija, Milić, Sandra, Štimac, Davor, Franjić, Neven, Pavletić Peršić, Martina, Mijandrušić-Sinčić, Brankica |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Popis: |
OBJECTIVE: The aim of the present study was to investigate whether patients with inflammatory bowel disease (IBD) have some degree of renal involvement. Furthermore, we were investigated whether this connection is related to active bowel disease. PATIENTS AND METHODS: In this cross-sectional study 50 patients mean age 47.1±16.5 years with a diagnosis of IBD were recruited from September 2012 to September 2013. The diagnosis of IBD was based on clinical history, endoscopic, histological and radiological findings. Disease activity was assessed using Mayo score for ulcerative colitis (UC), and CDAI for Crohn’s disease (CD) as well. There were and 38% patients with UC and 62% patients with CD. For this analysis purpose, patients were stratified according the disease (CD vs UC) and according to the disease activity (active IBD vs inactive IBD). RESULTS: The prevalence of abnormal proteinuria in UC and CD patients was 21.1% and 29% respectively. Proteinuria wasn't associated with IBD activity. Also, it wasn't associated with disease duration. On the other hand, eGFR showed negative correlation with disease activity in CD patients (r=-0.569 ; p=0.05), while there was no statistically significant correlation between active UC and eGFR (r=0.343 ; p=NS). CONCLUSION: Abnormal proteinuria is quite frequent in patients with IBD. It is not associated with disease activity. Furthermore, it seems that patients with IBD have some degree of glomerular damage, mainly those with CD. Further, larger and prospective studies that will investigated this association are needed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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