| Autor: |
Barbarić, Joško, Košić, Ivona, Imbrišić, Katarina, Žižek, Krunoslav |
| Přispěvatelé: |
Đaković, Marijana Miljanić, Snežana, Šantić, Ana, Vianello, Robert |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Popis: |
Fluidized bed melt granulation is an emerging process technology by which powders are enlarged using solid, low melting point binders. In this research, granulation of two pharmaceutical excipients, lactose monohydrate and microcrystalline cellulose, has been investigated. Melting of solid polyethylene glycol enables the formation of liquid bridges between particles which are necessary for enlargement to occur. In-situ granulation tests were performed in a lab-scale processing unit, fluidized bed granulator. Particle size distributions indicate a significant enlargement of lactose monohydrate/polyethylene glycol system. Additionally, granulation has substantially improved powder flowability which contributes to better tabletting. Enlargement of microcrystalline cellulose using polyethylene glycol as a binder was unsuccessful. Therefore, study of granulation phenomenon is directed towards detection of powder-binder interface parameters for microcrystalline cellulose/polyethylene glycol and lactose monohydrate/polyethylene glycol systems. Contact angle measurement technique using a goniometer has been applied for characterization of two interfaces of interest. Contact angles of three test liquids with well known surface energies were determined on substrates of microcrystalline cellulose, lactose monohydrate and polyethylene glycol. Two parametric models were used for quantitative prediction of interactions. Surface free energies of each phase, interfacial energies of interest and corresponding values of thermodynamic work of adhesion and spreading coefficients were estimated using Owens-Wendt and Wu models. Adhesion parameters indicate weak interactions between microcrystalline cellulose and polyethylene glycol with high possibility of phase dewetting and consequently on the inability for granulation of this system. Additionally, interface parameters indicate the possibility for establishment of considerable interactions between lactose monohydrate and polyethylene glycol. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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