| Autor: |
Šormaz, Sara, Tomašević, Matea, Sekulić, Ramona, Perić, Elena, Vuković, Ana, Vuković, Rosemary, Štolfa Čamagajevac, Ivna, Blažetić, Senka, Balog, Marta, Heffer, Marija |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Popis: |
Prolonged exposure of the body to the different stress conditions can cause increase in reactive oxygen species (ROS) production. At low concentrations, ROS are useful in some physiological processes, whereas higher concentrations can cause oxidative cell damage and thus play a major role in the pathogenesis of various human diseases. The aim of this study was to elucidate the impact of chronic stress on the oxidative stress development and antioxidative response in the liver of non- ovariectomized (NON-OVX) and ovariectomized (OVX) adult female rats. As an indicators of oxidative stress and antioxidative response, the activities of catalase (CAT), glutathione- reductase (GR) and superoxide-dismutase (SOD) were measured. Results showed that chronic stress caused a significant increase in CAT activity in the OVX group of animals. The ovariectomy significantly reduced GR activity while SOD activity remained unchanged due to the ovariectomy and chronic stress exposure. Obtained results showed that both chronic stress and estrogene deficiency, either alone or in combination, could affect antioxidative liver status of adult female rats. Comparing these results with the results of antioxidative enzymes activities obtained in previous study conducted on the younger rats, exposed to the same chronic stress protocol, showed different liver antioxidative response.Changes in antioxidative response point to increased production of reactive oxygen species that could cause cell damage and could be associated with numerous pathological conditions of the liver. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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