| Autor: |
Barišić, Lidija, Dropučić, Maja, Rapić, Vladimir, Kirin, Srećko Ivan, Metzler-Nolte, Nils |
| Jazyk: |
angličtina |
| Rok vydání: |
2003 |
| Předmět: |
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| Popis: |
In continuation of our studies in the field of heteroannularly substituted ferrocene amino acids 1 (m, n = 0-3) and their derivatives, we reported about coupling of their N-Boc derivatives with L-alanine into oligopeptides 2 (m, n = 0-3 ; p, r = 1-2) using EDC/ HOBt protoco. A number of a ferrocene-containing oligopeptides with parallel substituting strands (NHCHRCO)n were prepared starting from 1, 1'-Fn(COOH)2 and studied as a beta-sheet models. It is worth mentioning that compounds 2 are the first example of ferrocene-containing oligomers with antiparallel strands. These conjugates containing 1, 1'-ferrocenylene unit as beta-turn inducer are expected to be better mimics of ordinary natural beta-sheets than the parallel ones. In the present work we have carried out a detailed structural study on possible interstrand contacts in oligopeptides 2. For this purposes we have analysed their IR and NMR spectra in solvents which themselves do not form hydrogen bonds. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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