| Popis: |
The development of new strategies to treat Parkinson’s disease suffers from many deficiencies. Common therapy that includes external administration of L-dopa to Parkinson’s disease patients is limited due to the lack of targeting ability.[1, 2] As an alternative for conventional therapeutic drugs, selenium nanoparticles (SeNPs) constitute an attractive carrier platform for targeted drug delivery into the brain.[3, 4] In this study, two different SeNPs were designed using polyvinylpyrrolidone (PVP) and polysorbate 20 (Tween) as surface modifiers. Their binding ability for dopamine and L-dopa was evaluated by steady-state fluorescence spectroscopy. The strongest interaction was observed between L-dopa and PVP-SeNPs. Thermodynamic analysis revealed that binding between Tween-SeNPs and L-dopa or dopamine predominantly occurs through van der Waals interactions and hydrogen bonds, while electrostatic interactions govern the binding of L-dopa or dopamine to the PVP-SeNPs. In all cases, interactions were exothermic and spontaneous. |
