| Popis: |
At least one thrombophilic mutation was observed in 41.6% of women with pregnancy complications vs. to 20.6% of women with normal pregnancies (p=0.003), factor V Leiden was observed in 15.8% cases and 7.8% controls, prothrombin 20210A in 5.9% cases and 2.9% controls and homozygosity for MTHFR 677T, in 19.8% cases and 9.8% controls. Double and triple thrombophilic mutations were detected in 6.9% women with pregnancy complications compared to none in the control group. Women with severe pregnancy complications and related venous thromboembolism have an increased frequency of genetic thrombophilic mutations. |
