| Autor: |
Žulj, Marinko, Steiner, Kristina, Steiner, Sabina, Tomić, Matej, Vezmar, Ana-Marija, Vuković, Mladen, Fenrich, Matija, Boban, Marko, Včev, Aleksandar |
| Přispěvatelé: |
Štabuc, Borut, Tepeš, Bojan, Stefanovič, Milan, Potrč, Stojan, Jelenc, Franc |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Popis: |
Introduction: Ulcerative colitis and Crohn’s disease are inflammatory bowel diseases with increased incidence over the years. Some of the affected patients undergo the surgical procedure due to disease. Anti-TNF agents have become part of standard treatment for patients with IBDs. Some of the studies show that 70% of patients affected with Crohn’s disease and 35% of patients with ulcerative colitis will need the surgical treatment, and many population-based studies show that anti-TNF agents may reduce the surgical rates. The aim of this study was to compare surgical rates of patients with and without anti-TNF agents treatment, duration of remission and frequency of disease relapses in those two types of therapy. Materials and methods: For this study, medical documentation of adult patients has been used. Those patients were treated at Clinical Hospital Osijek, at the Department of Gastroenterology and Hepatology from 2000. To 2014. They are all affected by ulcerative colitis or Crohn’s disease, some of them had to undergo surgical treatment during their disease. Results: The remission time was significantly shorter in patients who had no surgical operation in comparison with patients who had a surgical procedure along with receiving both conventional and biologic therapy (double-tailed independent T-test, p = 0.009). The duration of relapse was longer in patients who had surgical operation and received biologic and conventional therapy compared to patients who had only surgical and conventional therapy (double-tailed independent T-test, p=0.373) and those who didn’t have operation (double-tailed independent T-test, p=0.143). Patients who had operation and received both biologic and conventional therapy had second operation later than patients who only received conventional therapy (double-tailed independent T-test, p=0.311). Conclusion: Our study has demonstrated that patient who had received combined conventional and biologic therapy had better results compared to patients who had only conventional therapy. Those patients had fewer relapses which were shorter in duration, while the remission time was longer. Furthermore, the indication for the surgical procedure as final treatment option came noticeably later after the diagnose of inflammatory bowel disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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