| Popis: |
Hemorrhagic mucosal lesions in the stomach in the rat induced by an intragastrical application of 1 ml of 50 or 75% ethanol were aggravated by preceding lung damage provoked by an intratracheal instillatin of pyrogen-free saline or HCl (pH 1.75) or 50-h exposure to 100% oxygen. Due to the particular preceding aggravating circumstances, these lesions were taken to be of special kind, rather than ordinary. So far, it is not known whether and how antiulcer agents may influence these lesions. Rats received an intratracheal (i.t.) HCl instillation [1.5 ml/kg HCl(pH 1.75)](lung lesion), and an intragastric instillation of 96 % ethanol (gastric lesion ; 1ml/rat, 24 h after i.t. HCl instillation), and were sacrified 1 h after ethanol. Basically , in lung injured rats, the subseqent ethanol-gastric lesion was markedly aggravated. This aggravation, however, in turn, did not affect the severity of the lung lesions in the further period, at least for an 1-h observation. Taken intratracheal HCl- instillation as time 0, a gastric pentadecapeptid, GEPPPGKPADDAGLV, M.W.1419, coded BPC 157 (PL-10, PLD-116 ; 10 ľg, 10 ng, 10 pg), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg), were given [/kg, intraperitoneally (i.p.)](1) once, only prophylactically [as a pre-treatment (at-1 h), or as a co-treatment (at 0)], or only therapeutically (at + 18 h or + 24 h) ; (2) repeatedly, combining prophylactic/therapeutic regimens [(-1 h) + (+24 h) or (0) + (+24 h)] or therapeutic/therapeutic regimens [(+ 18 h) + (+ 24 h)]. In general, the antiulcer agents did protect against ethanol gastric lesions regardless of the presence of the severe lung injury, in all of the used regimens. Of note, combining their prophylactic and salutary regimens (at - 1 h/ +24 h, or at 0/ +24 h) may increase the antiulcer potential, and the effect that han been not seen already with single application, became prominent after repeated treatment. |
