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INTRODUCTION: Chronic liver disease is an important complication observed in haemophilia patients due to viral infections transmitted during treatment with factor concentrates. Our objective was to examine synthetic liver function parameters [fibrinogen, factor V (FV), albumin and Glu-plasminogen] in haemophilia B (HB) patients. METHODS: The study group consisted of 41 HB patients, aged 2-84 years, divided into two groups according to age: HB1≤18 years (N=15) and HB2>18 years (N=26), and 41 healthy male controls (HMC) aged 6-76 years. The Clauss method was used for the determination of fibrinogen concentrations (Dade Thrombin, Sysmex CS5100, Siemens) whereas FV activities were measured by the one-stage clotting assay (Atellica COAG360, Siemens). Albumin concentrations were measured using the bromocresol green colorimetric method (Cobas c501, Roche Diagnostics), whereas Glu-plasminogen was assayed using the ELISA method (Technoclone). The MedCalc® Software was used for statistical analysis. RESULTS: Higher median fibrinogen concentration (3.1 g/L) was encountered in HB patients (range: 2.7-3.6 g/L), compared to the HMC group (median 2.5 g/L ; range: 2.3-2.8 g/L), resulting in a statistically significant difference (P |
