| Autor: |
Bago, Josip, Belošić Halle, Željka, Troskot Perić, Rosana, Marušić, Marinko, Bakula, Vinko, Kučušec, Nastja, Pevec, Branko, Majstorović, Karolina |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
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| Popis: |
Antibiotic resistance decreses success of H. pylori eradication. Recently published results show a low rate of resistance and better compliance with moxifloxacin based regiments. Wherher 7 days moxifloxacine with lansoprasole and amoxycillin can be compared with 10 days moxifloxacine with lansoprasole and amoxycillin according to moxifloxacin resistance. Patients with non-ulcer dyspepsia and culture and histology positive H. pylori infection and (n=150)were randomly assigned into two groups. The first group (n=75) receive moxifloxacin 400 mg/d during 7 days and the other group (n=75) received moxifloxacin 400 mg/d during 10 days. All patients receive amoxycillin 1 g twice daily, lansoprasole 30 mg twice dailiy during 7 days. All H. pylori cultures were tested for sensitivity to moxifloxacin. 138 patients (92%) completed the study, 68 in the first group and 70 in the second. Eradicetion rates were, in the 7 days moxifloxacin group, 87%(57/68) and 90% in the second (63/70) according to the PP analysis ; p=n.s. Among 129 patients (86% of entire study group), 6% of strains were primary resistant to moxifloxacin. Eradication of moxifloxacin sensitive/resistant strains was 98%/66%, p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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