| Popis: |
Metastasis of cervical carcinoma in uterine leiomyoma is a rare event, and it was seldom reported about. Recently, we have observed one unusual case of invasive cervical carcinoma spreading into the endocervicaly sited leiomyoma, that was histologically confirmed as atypical (or symplastic) leiomyoma. We could not find any data in the available literature concerning this matter. We report a case of a 74-years old patient who underwent surgery due to cervical carcinoma, presented at stage Ib. Surgical specimen showed infiltrative tumour of the cervix, measuring 1, 5 cm in greatest diameter and three solid, firm, white, sharply circumscribed nodules. Two of the nodules were intramural, up to 3 cm in greatest diameter, located in body of the uterus and were histologically confirmed as leiomyomas with marked hyalinization. The third nodule was located in the endocervix, close to the infiltrative tumour, measuring 1 cm in geatest diameter. Histologically it was composed of bizzare smooth muscle fibers. Variation in size and shape, hypercromatic nuclei and multinucleated forms were present, but no increased mitotic activity nor coagulation necrosis was evident. Within this tumour small solid nests of atypical epithelial cells resembling those in cervical carcinoma were found. An extensive immunohistochemical examination (Cytokeratine MBF 116, Cytokeratine 10/13, Desmin, PCNA, Ki-67 and p53, all DAKO) was provided, and the given results were discussed in the scope if different proliferation potential of both tumours. |
