| Autor: |
M. Cutolo, J. Vojinovic, A. Tincani, S. Soldano, L. Andreoli , F. Dall’Ara, F. Salaffi , R. Ionescu , K. Simic Pasalic, I. Balcune , I. Ferraz-Amaro, M. Tlustochowicz, I. Butrimiene, E. Punceviciene, N. Toroptsova, S. Grazio, J. Morovic-Vergles, P. Masaryk , K. Otsa, M. Bernardes, V. Boyadzhieva, A. Sulli |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Popis: |
Background: Vitamin D (25(OH)D) deficiency seems a distinct risk factor influencing prevalence and severity of several autoimmune diseases. Several studies suggest that low serum concentrations of vitamin D are frequent in rheumatoid arthritis (RA) patients, and an inverse relationships have been reported between 25(OH)D serum concentrations and disease activity or disability. Objectives: European multicentre cross-sectional study to collect data on vitamin D serum concentrations in RA patients from different countries, and to investigate the relationship with disease activity, disability and quality of life in a large population. Methods: The survey involved 625 RA patients (mean age 55±11 years, mean disease duration 11±9 years) and 276 age and sex-matched healthy subjects from 13 European countries. Serum samples for 25(OH)D measurement were collected during winter time (December-March) and analyzed in a central laboratory using chemiluminescence immunoassay (DiaSorin). Thirty-six percent of RA patients were treated with vitamin D analogues. Patient past medical history, Rheumatoid Arthritis Impact Diseases (RAID) score, Health Assessment Questionnaire (HAQ) and DAS28-CRP were also collected. Statistical analysis was performed by non parametric tests. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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