| Popis: |
The ratio of emulsifiers in formulation can affect, apart from the emulsion stability and viscosity, the drug release profile. Therefore, in order to achieve the desired properties of the formulation, amount of emulsifiers have to be carefully optimized. The aim of the present study was to investigate the influence of the emulsifiers ratio in the cream formulation on the release profile of active substance, emulsion stability and its viscosity. Ratio of Cetyl alcohol, Stearyl alcohol and Cetomacrogol 1000 have great impact on viscosity, release rate of mupirocin from cream base, as well as stability of the emulsion. In order to achieve good physical properties and desired release of mupirocin, the concentrations of mixed emulsifiers should carefully optimized considering all these three parameters. |
