| Popis: |
Purpose: To detect gender differences in the morphology and function of the systemic right ventricle (SRV) in patients with transposition of the great arteries (TGA). Methods or Background: Cine steady-state free precession cardiac MRI sequences were acquired using a 1, 5T scanner in 25 patients with SRV (age range 19-68, 13 males): 16 with atrial-switch repair for D-TGA and 9 with congenitally-corrected TGA. SRV volumetry was performed using a standard procedure. Mean longitudinal SRV strain was measured on a 4- chamber cine view, and mean circumferential SRV strain at three cine short- axis images based on feature-tracking. Late- gadolinium enhancement (LGE) scanning was performed in 22 patients and visually assessed. Numerical parameters of SRV function were compared between genders using independent samples T-test, whereas differences in LGE were assessed using Chi-Squared test. Results or Findings: Male patients with SRV, compared to their female counterparts, had significantly larger indexed SRV enddiastolic volume (139±47ml/m2 vs. 104±18ml/m2, p=0.025), lower SRV ejection fraction (39±13% vs. 52±5%, p=0.003) and SRV LGE more commonly present (9/12 vs. 1/10, p=0.002). Males had lower mean longitudinal SRV strain (-11.3±2, 8% vs. -16.4±2.4%, p |
