| Autor: |
Bilic, Ervina, Grkovic, Lana, Pulanic, Drazen, Bilic, Ernest, Nemet, Damir, Pavletic, Steven Z |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Popis: |
Introduction: Neurologic complications in chronic graft versus host disease (cGVHD) after hematopoietic stem cell transplantation (HSCT) may include peripheral neuropathy. A significant number of cGVHD patients experience painful muscle cramps and neuropathic pain (NeP). Small fiber neuropathy (SFN) may be the cause of NeP and it can be diagnosed with quantitative sensory testing (QST). Methods: Ten patients with cGVHD were examined and QST was performed (Pathway CHEPS). The patients also filled the Pain Detect questionnaire with final goal to diagnose the NeP and to validate the NeP treatment. Results: Six out of 10 patients reported pain and muscle cramps at the time of presentation and 4 of them met the criteria for NeP according to Pain Detect questionnaire. In all patients with NeP the QST disclosed affection of C and A-delta fibers (elevated threshold for pain, heat and cold sensation). In five non-NeP patients QST showed affection of only A-delta fibers. Conclusion: Neuropathy in cGVHD may have various causes and patterns. SFN may be the cause of NeP. According to our preliminary results, it is possible that A-delta fibers in cGVHD are affected first, in the period before NeP, while the affection of C and A-delta fibers presents later, after patients develop NeP. Neurologic complications and pain in cGVHD may have major impact on the functional status, quality of life and long term outcomes of cGVHD patients. Early recognition and proper diagnostics of SFN and NeP may contribute to the better treatment of pain in cGVHD patients |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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