| Autor: |
Matokanović, Mirela, Soldo, Franciska, Rumora, Lada, Barišić, Karmela |
| Přispěvatelé: |
Dumić, Jerka, Kovarik, Zrinka, Varljen, Jadranka |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
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| Popis: |
Chronic obstructive pulmonary disease (COPD) is a disease defined by progressive development of irreversible airflow limitation typically determined by reduction of quantitative spirometric parameters like forced expiratory volume at 1s (FEV1) and the ratio of FEV1 to forced vital capacity (FVC, FEV1/FVC). The current understanding of pathogenesis includes complex interaction between environmental factors and genetic predisposition. The major environmental risk factor is cigarette smoke, while candidate genes that may influence a person's risk for COPD development are still under study. Toll like receptors are members of transmembrane proteins that recognize conserved molecular motifs of viral and bacterial origin and initiate innate immune response. In COPD patients, recurrent infections of the lower bronchial tree with different bacteria and viruses, are present, suggesting a defect in immune response initiation. Therefore, the aim of this study was to investigate the potential association of polymorphisms in TLR2 (Arg753Gln) and TLR4 (Asp299Gly) genes and risk of COPD. The study group comprised of patients with COPD (n=106) and healthy controls (n=48). COPD was diagnosed by pulmonology specialist according to clinical examination and spirometry results FEV1/FVC < 0.70 and FEV1 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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