| Autor: |
Kusec, Vesna, Bilic, Karmen, Jelcic, Jozo, Giljevic, Zlatko, Smalcelj, Ruzica, Kastelan, Darko, Perkovic, Zdravko, Korsic, Mirko, Szekeres, Thomas |
| Jazyk: |
angličtina |
| Rok vydání: |
2003 |
| Předmět: |
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| Popis: |
Osteoprotegerin is an important factor in the regulation of bone turnover. The function of this soluble receptor for osteoprotegerin ligand/osteoclast differentiation factor is blocking its binding and activation of ODAR/RANK (osteoclast differentiation and activation receptor) on osteoclast surface and arresting terminal phase of its differentiation, reduction of activation of mature osteoclasts and stimulation of its apoptosis. The aim of this study was measurement of osteoprotegerin in the postmenopausal osteoporosis and renal osteodystrophy after kidney transplantation, metabolic disorders of different bone turnover intensity. This study comprised 42 women with postmenopausal osteoporosis and 40 kidney transplant recipients. The following biochemical parameters were determined by commercial ELISA kits: osteoprotegerin (Osteoprotegerin, Biomedica), bone alkaline phosphatase (Alkphase B, Metra Biosystems) and telopeptide (Crosslaps Serum, Osteometer). In kidney transplant recipients bone alkaline phosphatase (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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