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Asthma is a chronic inflammatory disease of the airways in which different imunocompetent cells are involved. Inflammation in asthma is also a systemic phenomenon as well as systemic inflammation influences the control of asthma. Based on this facts inflammatory biomarkers could have an important role in the management of asthma. To investigate the role of different biomarkers of inflammation in the management of childhood asthma. 61 consecutive asthmatic children (age 11±4, 31 girls) were studied. We assessed control of disease (based on lung function, symptoms, rescue medication use), and divided them in two groups (controlled [C], n=28 ; and non-controlled [NC], n=33). Exhaled NO, hs-CRP and differential leukocyte count in peripheral blood were measured. Exhaled NO (NC, 60, 9 ppb vs C 29, 4 ppb), mean serum hs-CRP levels (1, 52 mg/L vs 0, 96 mg/L) and eosinophil count (9, 1/uL vs 4, 7/uL) were significantly higher in children with uncontrolled asthma (P |
