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AIM: To investigate the impact of written instructions about nature, characteristics, intensity and duration of pain on patient’s pain perception and to estimate its correlation with personality traits. Furthermore, analgesic consumption during the first week of orthodontic treatment was assessed. MATERIALS AND METHODS: Sixty-eight healthy orthodontic patients (median age 14, 46% female) enrolled for orthodontic treatment were assigned to the study (n = 34) and the control group (n = 34) using computer randomization. Bonding of 0.022″ x 0.028″ slot brackets was performed in the maxillary arch from first molar to first molar and a 0.016″ NiTi archwire was used for alignment. All 68 subjects got verbal information on potential pain occurrence and pain control. Participants in the study group also received detailed written information on post treatment pain. Pain intensity was evaluated using the Numerical Rating Scale (NRS) right after the placement of fixed orthodontic appliance (T0), 2 days (T1), and 7 days (T2) after the placement. Analgesic consumption in the first week was assessed as yes/no, with participants who took it on more than 4 occasions being excluded. Patients’ personality traits ; extraversion, neuroticism, agreeableness, openness, and consciousness were examined by the Big Five Inventory (BFI). TSALD (Tooth Size - Arch Length Discrepancy) analysis was carried out on initial maxillary dental casts using digital software OrthoCADⓇ (Align Technology, San Jose, California, USA). Participants and clinicians were blinded to group assignment. RESULTS AND CONCLUSION: TSALD for the study group was -0.4 ± 4.0 and for the control group +0.4 ± 3.8. There was no statistically significant difference between the groups (p=0.944). In addition, no statistically significant difference in pain perception at T0, T1 and T2 was observed. The highest rate of pain in both groups was recorded at T1 (p |