| Autor: |
Soderquest, Katrina, Walzer, Thierry, Zafirova, Biljana, Klavinskis, Linda S., Polić, Bojan, Vivier, Eric, Lord, Graham M., Martín-Fontecha, Alfonso |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
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| DOI: |
10.4049/jimmunol.1004122 |
| Popis: |
It is uncertain whether NK cells modulate T cell memory differentiation. By using a genetic model that allows the selective depletion of NK cells, we show in this study that NK cells shape CD8(+) T cell fate by killing recently activated CD8(+) T cells in an NKG2D- and perforin-dependent manner. In the absence of NK cells, the differentiation of CD8(+) T cells is strongly biased toward a central memory T cell phenotype. Although, on a per-cell basis, memory CD8(+) T cells generated in the presence or the absence of NK cells have similar functional features and recall capabilities, NK cell deletion resulted in a significantly higher number of memory Ag-specific CD8(+) T cells, leading to more effective control of tumors carrying model Ags. The enhanced memory responses induced by the transient deletion of NK cells may provide a rational basis for the design of new vaccination strategies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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