Immunohistochemical Analysis of Cytokeratin 7/10/19 and Β-Catenin Protein Expression in Patients with Hepatocellular Carcinoma after Liver Transplantation

Autor: Škrtić, Anita, Mrzljak, Anna, Gašparov, Slavko, Čolić Cvrlje, Vesna, Naumovski Mihalić Slavica, Škegro, Dinko, Filipec Kanižaj Tajana, Guštin, Denis, Jadrijević, Stipislav, Kocman, Branislav
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Popis: Cytokeratin (CK) 10 is associated with invasiveness of hepatocellular carcinoma(HCC). Expression of CK7 and CK19 in HCC suggests worse prognosis based on a hihger HCC recurrence rate in in patients with CK overexpression after liver transplantation (LTx). The most frequently mutated genes in HCC are p53 and beta-Catenin. The aim of this study was to assess the occurrence of CK 7(10/19 and beta Catenin, alone or in combination, in comparison with FISH analysis of 17p13.1, clinico-pathological features and overall survival in HCC transplanted patients.
Databáze: OpenAIRE