| Popis: |
Haemangiopericytoma is a rare malignant vascular tumor deriving from pericytes. It is common in the extremities and the retroperitoneum, but extremely rare in the gastrointestinal tract. we report case of hemangiopericytoma in the gastroesophageal region. A 56-year– old patient was treated with H2-receptor antagonist for dyspeptic symptoms, which appear three month ago. Therapy was not successful and gastroendoscopy was performed in March 2001. Gastroendoscopy revealed slightly reddish ventricular mucosa with normal rugal folds and sessile, polypoid, grayish mass with rough surface located at the gastroesophageal border. Pathohistological examination of polypoid specimens from gastroesophageal region revealed vascular tumor covered by squamous epithelium. The hallmarks of the tumor were numerous branching, slitlike capillary channels with “ staghorn” appearance, and large gaping sinusoidal spaces enclosed within nests of ovoid cells. Vascular invasion, mitotic activity, giant cells and necrosis were not found. Immunohistochemical analysis showed diffuse and strong reactivity for vimentin and focall, low or moderate, reactivity for actin, S-100 and smooth muscle actin. Proliferative index measured by PCNA and Ki-67 ranged between 2% and 13% (median 11.2) and 5% and 18% (median 7.6), respectively. Diagnosis of hemangiopericytoma with low malignant potential was established. Almost two years after intervention the patient is still alive and shows no signs of tumor spread. |
