Detection of Chlamydia pneumoniae in atherosclerotic plaques in the walls of arteries of lower extremities from patients undergoing bypass operation for arterial obstruction

Autor: Kuo, C.c., Coulson, A.S., Campbell, L.A., Cappuccio, A.L., Lawrence, R.D., Wang, S.p., Grayston, J.
Zdroj: Journal of Vascular Surgery; July 1997, Vol. 26 Issue: 1 p29-31, 3p
Abstrakt: Purpose: To study surgically excised vascular tissue from lower extremities for the presence of Chlamydia pneumoniae, to extend the previously described association of the organism with atherosclerosis. Methods: Arterial biopsy specimens obtained from femoral and popliteal arteries during bypass operation for claudication were examined by immunocytochemical analysis and polymerase chain reaction for the presence of organisms. Results: C. pneumoniae was detected in atherosclerotic plaques by either method in either artery of 11 of 23 patients (48%). Eight of 21 popliteal and three of 18 femoral arteries had positive results. Conclusions: Detection of C. pneumoniae in peripheral arteries indicates that the organism is widespread in atherosclerosis of the vascular system. (J Vasc Surg 1997;26:29-31.)
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