| Autor: |
Bronsky, E.A., Druce, H., Findlay, S.R., Hampel, F.C., Kaiser, H., Ratner, P., Valentine, M.D., Wood, C.C. |
| Zdroj: |
The Journal of Allergy and Clinical Immunology; May 1995, Vol. 95 Issue: 5 p1117-1122, 6p |
| Abstrakt: |
Intranasal ipratropium bromide has been shown to significantly reduce rhinorrhea. Use of a freon-propelled intranasal preparation has resulted in side effects associated with the drying properties of the propellant. The purpose of the present trial was to study the safety and efficacy of a new isotonic aqueous ipratropium bromide nasal spray pump, specifically in patients with perennial nonallergic rhinitis. Two hundred thirty-three patients participated in an 8-week double-blind parallel comparison of ipratropium bromide nasal spray with its vehicle, a saline solution. Treatment with the ipratropium spray resulted in a 30% reduction in rhinorrhea; this reduction was significantly greater than that seen with the saline vehicle. There was a modest reduction in postnasal drip, sneezing, and congestion with both treatments, which may be attributable to the salutary effects of the saline solution. Patients also perceived a significant reduction in the degree to which rhinorrhea interfered with their daily activities and moods. Treatment was well tolerated, with no drug-related systemic adverse events and no evidence of nasal rebound on discontinuation of treatment. Minor, infrequent episodes of nasal dryness and epistaxis were the only significant adverse events reported; these did not limit treatment. (J ALLERGY CLIN IMMUNOL 1995;95:1117-22.) |
| Databáze: |
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