| Autor: |
Ghosh, Subrata, Sinha, Saikat, G. B. Drew, Michael |
| Zdroj: |
Organic Letters; August 2006, Vol. 8 Issue: 17 p3781-3784, 4p |
| Abstrakt: |
Asymmetric synthesis of densely functionalized bicyclic frameworks for entry into bacillariolides I/III and ent-bacillariolide II is reported. The key features are ring-closing metathesis of a pair of diastereomerically related dienes obtained through a stereodivergent route from a R-()-glyceraldehyde derivative, transformation of a nonstereoselective cyclopentene ester enolate alkylation process to a completely stereoselective one through alkylation of a bulky ester enolate with a bulky electrophile, and a remote silyloxymethyl group directed epoxidation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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