| Autor: |
Dorcier, Antoine, Han Ang, Wee, Bolaño, Sandra, Gonsalvi, Luca, Juillerat-Jeannerat, Lucienne, Laurenczy, Gàbor, Peruzzini, Maurizio, D. Phillips, Andrew, Zanobini, Fabrizio, J. Dyson, Paul |
| Zdroj: |
Organometallics; August 2006, Vol. 25 Issue: 17 p4090-4096, 7p |
| Abstrakt: |
Reaction of the dimer (5-C5Me5)RhCl(2-Cl)2with 2 or 4 equiv of the water-soluble phosphine 1,3,5-triaza-7-phosphatricyclo3.3.1.1decane (pta) affords Rh(5-C5Me5)(pta)Cl2 and Rh(5-C5Me5)(pta)2ClCl, respectively. Both complexes have been characterized in solution by NMR spectroscopy and in the solid state by single-crystal X-ray diffraction, the latter as the chloride and BPh4-salts. In addition, the rhodium(I) complexes Rh(5-C5Me5)(CO)(pta) and Rh(5-C5H5)(pta)2 have been prepared from Rh(5-C5Me5)(CO)2 and Rh(5-C5H5)(PPh3)2, respectively, by reaction with pta. An in vitro evaluation of these compounds, together with Os(6-C10H14)(pta)Cl2 and the well-characterized antimetastasis drug Ru(6-C10H14)(pta)Cl2, RAPTA-C, was undertaken using HT29 colon carcinoma, A549 lung carcinoma, and T47D breast carcinoma cells. In the HT29 cell line, the two nearest congeners to Ru(6-C10H14)(pta)Cl2, viz., Rh(5-C5Me5)(pta)Cl2 and Os(6-C10H14)(pta)Cl2, demonstrated very similar cytotoxicity profiles. Rh(5-C5Me5)(pta)Cl2 proved significantly more cytotoxic in A549 cells and Rh(5-C5Me5)(pta)2ClCl 3-fold more cytotoxic in T47D cells, both relative to RAPTA-C. These data suggest that the development of organometallic anticancer drugs based on the neighboring elements to ruthenium should not be overlooked. |
| Databáze: |
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