Hydrogels Formed by Multiple Peptide Ligation Reactions To Fasten Corneal Transplants

Autor: Wathier, Michel, Starck Johnson, C., Kim, Terry, W. Grinstaff, Mark
Zdroj: Bioconjugate Chemistry; July 2006, Vol. 17 Issue: 4 p873-876, 4p
Abstrakt: A stable cross-linked hydrogel was formed under mild aqueous conditions using pseudoproline peptide ligation chemistry. A cysteine-terminated lysine dendron containing four cysteines and a PEG macromolecule modified with terminal ester aldehydes were prepared. Upon mixing, the two macromers gave a stable hydrogel. This hydrogel along with sutures was used to successfully secure a corneal transplant in vitro.
Databáze: Supplemental Index