| Autor: |
Kralj, Ana, Kehraus, Stefan, Krick, Anja, Eguereva, Ekaterina, Kelter, Gerhard, Maurer, Martina, Wortmann, Andreas, Fiebig, Heinz-Herbert, M. König, Gabriele |
| Zdroj: |
Journal of Natural Products; July 2006, Vol. 69 Issue: 7 p995-1000, 6p |
| Abstrakt: |
The fungus Emericella nidulansvar. acristata was isolated as an endophyte from a Mediterranean green alga. Cultivation of this fungus yielded two new compounds, arugosins G (1) and H (2), together with the known metabolites 3−9. Arugosins (1−4) are benzophenone derivatives, biosynthetically related to the xanthones 5, 6, and 9. The indole alkaloid 7displayed antitumor activity in a panel of 36 human tumor cell lines, exhibiting a mean IC50value of 5.5 g/mL in an in vitro survival and proliferation assay. Furthermore, compounds 3and 4showed moderate antitumor activity toward individual tumor cell lines. None of compounds 1−8exhibited any immunostimulatory activity assessed as the capacity to induce cytokines in PBMCs from healthy donors. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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