Low dose response of human lymphocytes in vitro and its dependence on the antioxidant status of donor persons

Autor: Koteles, G.J., Bojtor, I., Bognar, G., Otos, M.
Zdroj: International Journal of Low Radiation; January 2003, Vol. 1 Issue: 1 p147-154, 8p
Abstrakt: The individual responses of persons were studied in vitro by lymphocyte micronucleus assay following X-irradiations of 0.7 and 0.25 Gy. Linear correlations of a different coefficient, R, were found with the normal total antioxidant level (TAS value) of the donors' sera: the higher the antioxidant status the less the radiation-induced micronucleus increment. The cytogenetic effect of low doses could be significantly protected above approximately 1.6 mmol l-1 of TAS. Accordingly, the resistance in population, as it were, could be increased by long-lasting consumption of vitamins C and E when the initial TAS values must have been elevated.
Databáze: Supplemental Index