| Autor: |
Lin, Chang, Lee, Eunkyung, Jin, Mei, Yook, Jumin, Quan, Zhejiu, KB, Kyungmi, Moon, Tae, Kim, BF, Kim, Keuk, Lee, Seung, Chang, Hyeun |
| Zdroj: |
Planta Medica; July 2006, Vol. 72 Issue: 9 p786-791, 6p |
| Abstrakt: |
The effect of deoxypodophyllotoxin (DPT) isolated from ANTHRISCUS SYLVESTRIS Hoffm. was evaluated in an IN VIVO animal model for antiasthmatic activity. DPT (1.0 to 5 mg/kg) was given orally to ovalbumin (OVA)/alum-induced asthmatic mice. DPT reduced the number of infiltrated eosinophils in bronchoalveolar lavage (BAL) fluid in a dose-dependent manner. Dexamethasone (5 mg/kg), which was used as a positive control, also strongly inhibited the number of infiltrated eosinophils. The effect of DPT on a transcript profile in a murine asthma model was determined by RT-PCR, which showed that DPT decreased the mRNA levels of the Th2 cytokines. Northern blot analysis showed that DPT also reduced both the eotaxin and arginase I mRNA levels in a dose-dependent manner. |
| Databáze: |
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