| Autor: |
GAPE, P HILIPPE A, ERARD, B ENEDICTE G, AVE, H ELENE C, EVAUX, I SABELLE D, ILMER, E TIENNE V, ECOMTE, M ARIE-C HRISTINE L, RANDCHAMP, B ERNARD G |
| Zdroj: |
British Journal of Haematology; July 1997, Vol. 98 Issue: 1 p234-239, 6p |
| Abstrakt: |
The t(12;21) is a recurring chromosomal abnormality in acute lymphoblastic leukaemias (ALLs) which results in the production of an ETV6-AML1 fusion gene. The association between t(12;21) and the deletion of the untranslocated allele of ETV6 is among the most frequent abnormalities observed in B-lineage ALLs in children. In order to study the proteins encoded by ETV6ETV6-AML1, we raised polyclonal antibodies directed against a recombinant peptide corresponding to the junctional region of ETV6-AML1. Cell lysates from various leukaemic cell lines, and from children with B- and T-lineage ALLs, were studied by Western blot. |
| Databáze: |
Supplemental Index |
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