| Autor: |
eil, F elix K, alhs, P eter K, aas, O skar A. H, ritsch, G erhard F, eiter, E lisabeth R, annhalter, C hristine M, echner, K laus L, eitner, G erda L, reinix, H ildegard T. G |
| Zdroj: |
British Journal of Haematology; April 1997, Vol. 97 Issue: 1 p161-164, 4p |
| Abstrakt: |
We present a patient who underwent sibling allogeneic BMT because of refractory Ph+ve ALL and remained BCR-ABL-positive after marrow grafting. Haemopoietic precursor cells were predominantly BCR-ABL-negative and of donor origin. In T cells an exclusively donor genotype was demonstrated. Despite donor leucocyte infusion (DLI), 20 weeks after BMT BCR-ABL fusion mRNA increased in semiquantitative polymerase chain reaction and leukaemic infiltration of the patient's bone marrow was seen. After a second course of DLI the patient achieved sustained molecular remission but he developed severe graft-versus-host disease (GvHD) and died from bacterial sepsis 9 months after DLI. |
| Databáze: |
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