| Autor: |
Lang, Gerhard, I. Mitova, Maya, Ellis, Gill, van der Sar, Sonia, K. Phipps, Richard, W. Blunt, John, J. Cummings, Nicholas, L. J. Cole, Anthony, H. G. Munro, Murray |
| Zdroj: |
Journal of Natural Products; April 2006, Vol. 69 Issue: 4 p621-624, 4p |
| Abstrakt: |
Using HPLC/microtiter-plate-based generation of activity profiles the extract of a marine alga-derived fungus, identified as Gliocladium sp., was shown to contain the known strongly cytotoxic metabolite 4-keto-clonostachydiol (1) and also clonostachydiol (2) as well as gliotide (3), a new cyclodepsipeptide containing several d-amino acids. The absolute configuration of 1 was elucidated by reduction to 2, and two further oxidized derivatives of clonostachydiol (5, 6) were prepared and evaluated for biological activity. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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