| Autor: |
G. Ferguson, Colin, S. Bigman, Cleve, D. Richardson, Robyn, A. van Meeteren, Laurens, H. Moolenaar, Wouter, D. Prestwich, Glenn |
| Zdroj: |
Organic Letters; May 2006, Vol. 8 Issue: 10 p2023-2026, 4p |
| Abstrakt: |
Lysophospholipase D (lysoPLD), also known as autotaxin (ATX), is an important source of the potent mitogen lysophosphatidic acid (LPA). Two fluorogenic substrate analogues for lysoPLD were synthesized in nine steps from (S)-PMB-glycerol. The substrates (FS-2 and FS-3) show significant increases in fluorescence when treated with recombinant ATX and have potential applications in screening for this emerging drug target. |
| Databáze: |
Supplemental Index |
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