| Autor: |
Brenstrum, Tim, Clattenburg, Julie, Britten, James, Zavorine, Serguei, Dyck, Jeff, J. Robertson, Alan, McNulty, James, Capretta, Alfredo |
| Zdroj: |
Organic Letters; January 2006, Vol. 8 Issue: 1 p103-105, 3p |
| Abstrakt: |
Phosphorinanes are presented as a class of phosphine ligand suitable for organopalladium cross-coupling chemistry. Prepared via a direct double Michael addition of a monoalkyl- or arylphosphine to phorone followed by a Wolf−Kishner reduction, phosphorinanes are relatively inexpensive to manufacture and allow modification of one of the alkyl moieties permitting steric and electronic fine-tuning of the ligands. Library screening and applications of these ligands in the Suzuki, Sonogashira, ketone arylation, and aryl amination reactions are presented. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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