| Autor: |
J. Fleck, Thomas, Jack Chen, Jiong, V. Lu, Cuong, J. Hanson, Kari |
| Zdroj: |
Organic Process Research & Development; March 2006, Vol. 10 Issue: 2 p334-338, 5p |
| Abstrakt: |
FeCl3 catalyzed an isomerization-free Friedel−Crafts sulfonylation between 1-naphthalenesulfonyl chloride and halobenzenes. The coupled halide was then displaced using 35% hydrazine in DMSO to provide the Fischer indole precursor. Pure 5-chloro-2-pentanone was the key for a successful Grandberg modification of Fischer indole synthesis that effectively constructed both the indole core and side chain of the target molecule. The development of these methods enabled a rapid preparation of kilogram quantities of PHA-565272A. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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