| Autor: |
G. N. Russell, Michael, W. Carling, Robert, J. Street, Leslie, J. Hallett, David, Goodacre, Simon, Mezzogori, Elena, Reader, Michael, M. Cook, Susan, A. Bromidge, Frances, Newman, Robert, J. Smith, Alison, A. Wafford, Keith, R. Marshall, George, S. Reynolds, David, Dias, Rebecca, Ferris, Pushpindar, Stanley, Jo, Lincoln, Rachael, J. Tye, Spencer, F. A. Sheppard, Wayne, Sohal, Bindi, Pike, Andrew, Dominguez, Maria, R. Atack, John, L. Castro, José |
| Zdroj: |
Journal of Medicinal Chemistry; February 2006, Vol. 49 Issue: 4 p1235-1238, 4p |
| Abstrakt: |
The identification of a series of imidazo[1,2-b][1,2,4]triazines with high affinity and functional selectivity for the GABAA α3-containing receptor subtype is described, leading to the identification of a clinical candidate, 11. Compound 11 shows good bioavailability and half-life in preclinical species, and it is a nonsedating anxiolytic in both rat and squirrel monkey behavioral models. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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