| Autor: |
J. Comin, Maria, A. Parrish, Damon, R. Deschamps, Jeffrey, E. Marquez, Victor |
| Zdroj: |
Organic Letters; February 2006, Vol. 8 Issue: 4 p705-708, 4p |
| Abstrakt: |
A general synthetic strategy for the preparation of functionalized bicyclo[3.1.0]hexanes is described. The new approach employs a cross metathesis step designed to functionalize the appropriate terminal olefin of the bicyclo[3.1.0]hexane precursor and a carbene-mediated intramolecular cyclopropanation reaction on the corresponding diazo intermediate. This combined methodology allowed the diastereoselective introduction of chemically diverse substituents at the tip of the cyclopropane group, except in cases where the substituents consisted of electron-withdrawing groups where a competing [3 + 2] cycloaddition predominated. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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