Ratio between the number of Th1 and Th2 lymphocytes in the peripheral blood and concentration of proinflammatory cytokines in lochia of women with postpartum endometritis

Autor: Sukhikh, G., Kasabulatov, N., Van’ko, L., Ordzhonikidze, N., Veryasov, V., Danelyan, S.
Zdroj: Bulletin of Experimental Biology and Medicine; December 2005, Vol. 140 Issue: 6 p672-674, 3p
Abstrakt: We estimated the percentage of CD4+ lymphocytes synthesizing IFN-γ and IL-4 in the peripheral blood and measured the concentrations of IL-1, IL-6, and TNF-α in lochia of patients with postpartum endometritis. T lymphocytes with intracellular IFN-γ prevailed in women with physiological course of the postpartum period. The number of cells containing IL-4 increased in patients with postpartum endometritis. On days 5–7 after childbirth the concentrations of proinflammatory cytokines IL-1β and TNF-α in lochia of these patients were higher than in healthy postpartum women (by 1.4 and 2.7 times, respectively). The concentrations of cytokines IL-1β, TNF-α, and IL-6 increased most significantly in patients with postpartum endometritis and active viral infection (by 3.4, 4.2, and 1.6 times, respectively).
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