Synthesis of the C1–C26 Northern Portion of Azaspiracid-1: Kinetic versus Thermodynamic Control of the Formation of the Bis-spiroketalFinancial support was provided by the National Institutes of Health (GM63723). This publication was made possible in part by grant number P30 ES00210 from the National Institute of Environmental Health Sciences, NIH. The authors would also like to thank Professor Max Deinzer (OSU) and Dr. Jeff Morré (OSU) for mass spectral data, Rodger Kohnert (OSU) and Dr. Clemens Anklin (Brüker Biospin) for NMR assistance, Damien Kuiper (OSU) for synthetic assistance with sulfone 14 and aldehyde 9, and Dr. Roger Hanselmann (Rib-X Pharmaceuticals) for helpful discussions.

Autor: Zhou, Xiao-Ti, Carter, Rich G.
Zdroj: Angewandte Chemie. International Edition; March 2006, Vol. 45 Issue: 11 p1787-1790, 4p
Abstrakt: No Abstract
Databáze: Supplemental Index