Sevelamer hydrochloride reverses parathyroid gland enlargement via regression of cell hypertrophy but not apoptosis in rats with chronic renal insufficiency.

Autor: Nagano, Nobuo, Miyata, Sonoe, Abe, Megumi, Wakita, Sachiko, Kobayashi, Nami, Wada, Michihito
Zdroj: Nephrology Dialysis Transplantation; March 2006, Vol. 21 Issue: 3 p634-643, 10p
Abstrakt: Dietary phosphate restriction suppresses parathyroid hormone (PTH) secretion, synthesis, and parathyroid cell proliferation in experimental animals with chronic renal insufficiency (CRI), independently of serum calcium and 1,25(OH)2D3 levels. This study was conducted to examine whether sevelamer hydrochloride (sevelamer), a metal-free phosphate binder, could regress an advanced parathyroid gland (PTG) hyperplasia and enlargement in rats with CRI.
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