Convenient syntheses of [20,20,20‐2H3]‐arachidonic acid and [20,20,‐2H2]‐20‐hydroxyeicosatetraenoic acid

Autor: Falck, J. R., Anjaiah, Siddam, Raju Tuniki, Venugopal, Raj Gopal, V., Capdevila, Jorge H.
Zdroj: Journal of Labelled Compounds and Radiopharmaceuticals; March 2006, Vol. 49 Issue: 3 p245-252, 8p
Abstrakt: Deuterated arachidonic acid and 20‐HETE were prepared in good overall yields and high stereoselectivities. Key transformations include a trans‐specific vinyl dibromide reduction and Suzuki cross‐couplings to a lithium borate or a 9‐BBN borane. These standards are three and two mass units higher, respectively, than their naturally occurring counterparts and are useful in mass spectrometry analysis. Copyright © 2006 John Wiley & Sons, Ltd.
Databáze: Supplemental Index