| Autor: |
Roy, Mary, Langill, Coleen, Yonovitz, A. |
| Zdroj: |
The Journal of the Acoustical Society of America; April 1991, Vol. 89 Issue: 4 p1931-1932, 2p |
| Abstrakt: |
The use of gentamicin as an antimicrobial agent has been shown to produce as an untoward effect, ototoxicity. The purpose of this study was to investigate differential effects of gentamicin ototoxicity as a function of Rx timing with regard to circadian rhythms. Sprague‐Dawley rats received a daily subcutaneous dosage of 100 mg/kg of gentamicin. The rats were maintained on a light‐dark 12:12 illumination cycle with light commencing at 0000. One group of rats received gentamicin at 0200 with the other group at 1400. Hearing loss was assessed with the auditory brainstem response using pure‐tone stimuli of 8, 16, 24, and 32 kHz. These measures were obtained at baseline, 2 and 4 weeks after the initial dosing. Measures of blood‐gentamicin level and nephrotoxicity were contrasted for the groups. Ototoxicity was greater for gentamicin when given to the rodents during their diurnal rest span (0200) in comparison to their nocturnal activity span (1400). These circadian dependent effects are thought to be related to rhythmic variations in the disposition and accumulation of gentamicin in cochlear tissues. |
| Databáze: |
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| Externí odkaz: |
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