| Autor: |
Biglino, Alberto, Sinicco, Alessandro, Forno, Brunella, Pollono, Anna Maria, Sciandra, Mauro, Martini, Caterina, Pich, Piergiorgio, Gioannini, Paolo |
| Zdroj: |
Clinical Immunology and Immunopathology (Now Called Clinical Immunology); January 1996, Vol. 78 Issue: 1 p61-69, 9p |
| Abstrakt: |
Serum cytokine profiles, T-cell subsets, and general parameters of immune activation were evaluated in 15 patients with acute primary HIV-1 infection, and compared with those obtained from 18 patients with acute primary Epstein-Barr virus (EBV) infection and from 18 control subjects in order to elucidate possible defects of immune response to HIV in early phases of virus-host interaction. Mean CD4+cell count, serum concentrations of interleukin (IL)-2, IL-4, soluble IL-2 receptor (sIL-2R), tumor necrosis factor (TNF)-α,5′-neopterin, and β2-microglobulin were significantly lower in acute HIV-1 infection than in EBV infection. Both acute HIV-1 and EBV infections were characterized by significantly higher mean CD8+cell count and soluble CD8 antigen (sCD8) levels compared to control subjects, while acute HIV-1 infection was accompanied by the highest interferon (IFN)-γ serum concentrations. In primary HIV-1 infection, significant impairment of CD4+-mediated T-helper function may lead to viral escape and persistence of infection despite an early and vigorous CD8+T-lymphocyte activation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full Text from ScienceDirect