| Autor: |
Carney, David E., McCann, Ulysse G., Schiller, Henry J., Gatto, Louis A., Steinberg, Jay, Picone, Anthony L., Nieman, Gary F. |
| Zdroj: |
Journal of Surgical Research; August 2001, Vol. 99 Issue: 2 p245-252, 8p |
| Abstrakt: |
Background.The acute respiratory distress syndrome (ARDS) occurs in patients with clearly identifiable risk factors, and its treatment remains merely supportive. We postulated that patients at risk for ARDS can be protected against lung injury by a prophylactic treatment strategy that targets neutrophil-derived proteases. We hypothesized that a chemically modified tetracycline 3 (COL-3), a potent inhibitor of neutrophil matrix metalloproteinases (MMPs) and neutrophil elastase (NE) with minimal toxicity, would prevent ARDS in our porcine endotoxin-induced ARDS model. |
| Databáze: |
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