| Autor: |
Aliano, AN, Allen, TE, Brown, DJ, Cowden, WB, Grigg, GW, Kavulak, D, Lan, S |
| Zdroj: |
Australian Journal of Chemistry; 1984, Vol. 37 Issue: 11 p2385-2390, 6p |
| Abstrakt: |
Syntheses are described for N,N-dimethyl-2-[5'-(pyridin-2''-yl)-1',3',4'-thiadiazol-2'-ylthio]ethylamine; the homologous propylamine; the N,N-diethyl homologue; the 5'-phenyl analogue; and some substituted phenyl, pyrazinyl and pyrimidinyl analogues. Unlike the pyridin-4''-yl isomer previously described, these compounds proved but mediocre amplifiers of phleomycin-G in vitro against Escherichia coli. Testing in vivo against Ehrlich's tumour in mice was therefore confined to the pyridin-4''-yl compound and to N,N-dimethyl-2-(6'-methyl-2'-phenylpyrimidin-4'-ylthio)ethylamine: the first showed considerable amplifying power towards two phleomycins and a bleomycin; the second, only marginally less amplification towards the same phleomycins. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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