| Autor: |
Larijani, Bagher, Pajouhi, Mohammad, Bastanhagh, Mohammad Hasan, Sadjadi, Alireza, Aghakhani, Shahriar, Zare, Farhad, Sedighi, Nahid, Eshraghian, Mohammad Reza, Nadjafi, Amir Hossein, Amini, Mohammad Reza, Adibi, Hossein, Akrami, Seyed Mohammad |
| Zdroj: |
Therapy; November 2005, Vol. 2 Issue: 6 p883-888, 6p |
| Abstrakt: |
Introduction:There is no consensus on the appropriate management of benign cold nodules of the thyroid gland. This study addresses the problem in an iodine-deficient area, evaluating the efficacy of levothyroxine suppression therapy on a 2-year course. Methods: A total of 58 patients affected with benign cold nodules of the thyroid were enrolled. With a double-blind placebo-controlled design, levothyroxine (1.5––2 μμg/kg/day) was delivered to the 31 cases over 2 years. The consequences of this treatment were compared with 27 controls. Nodule size was measured with high-resolution ultrasonography. Results:In the treatment group, the mean volume on baseline was 12.8 ±± 11.9 ml and changed to 9.4 ±± 9.8, 12.4 ±± 16.7 and 10.8 ±± 9.7 ml in months 6, 12 and 24, respectively. In the placebo group, these figures were 13.0 ±± 10.2, 11.5 ±± 8.0, 11.7 ±± 13.6 and 11.6 ±± 8.5 ml, respectively. No significant difference between the two groups was observed. Conclusion:Thyroid-stimulating hormone suppression with levothyroxine for 2 years was not effective in reducing the size of benign cold nodules of the thyroid gland. |
| Databáze: |
Supplemental Index |
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