| Autor: |
Chandrachud, Lata M., Grindlay, G. Joan, McGarvie, Gail M., O'Neil, Brian W., Wagner, Eric R., Jarrett, William F.H., Campo, M. Saveria |
| Zdroj: |
Virology; August 1, 1995, Vol. 211 Issue: 1 p204-208, 5p |
| Abstrakt: |
We have previously shown that cattle vaccinated with L2, the minor structural protein of bovine papillomavirus-4 (BPV-4), do not develop alimentary papillomas upon challenge with BPV-4. Analysis of the B and T cell response in L2-vaccinated animals showed that the majority of the response was directed against the N-terminus and C-terminus of L2 with little response against the middle portion. Cattle were vaccinated with the N-terminus or the C-terminus of L2. The animals vaccinated with the N-terminus were completely protected from vital challenge, whereas the animals vaccinated with the C-terminus were not. Further analysis with synthetic overlapping peptides spanning the entire N-terminus mapped a B cell immunodominant epitope at amino acid 101-120. This epitope was recognised by all vaccinated animals. Copyright 1995, 1999 Academic Press |
| Databáze: |
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