| Autor: |
Gediya, L. K., Chopra, P., Purushottamachar, P., Maheshwari, N., Njar, V. C. O. |
| Zdroj: |
Journal of Medicinal Chemistry; July 2005, Vol. 48 Issue: 15 p5047-5051, 5p |
| Abstrakt: |
We have developed a procedure for the synthesis of N-hydroxy-N1-phenyloctanediamide (suberoylanilide hydroxamic acid (SAHA)), providing the product in 79.8% yield. SAHA is a potent inhibitor of histone deacetylase, induces differentiation and/or apoptosis in certain transformed cells in culture, and suppressed the growth of human prostate cancer LNCaP and PC-3 cell lines. The combination of SAHA with other compounds inhibited cell proliferation of LNCaP cells in additive fashion and resulted in synergistic growth inhibition. |
| Databáze: |
Supplemental Index |
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